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The Fukuyama coupling is a coupling reaction taking place between a thioester and an organozinc halide in the presence of a palladium catalyst. The reaction product is a ketone. This reaction was discovered by Tohru Fukuyama et al. in 1998. Advantages are high chemoselectivity, mild reaction conditions and the use of less-toxic reagents. : One advantage of this method is that the reaction stops at the ketone and does not proceed to a tertiary alcohol. In addition, the protocol is compatible with functional groups such as ketones, acetates, sulfides, aromatic bromides, chlorides and aldehydes. : The reaction (interrupted) has been used in the synthesis of biotin : This reaction was preceded by the conceptually related Fukuyama reduction. ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Fukuyama coupling」の詳細全文を読む スポンサード リンク
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